ea0056gp23 | Adrenal clinical | ECE2018
Chortis Vasileios
, Taylor Angela
, Doig Craig
, Walsh Mark
, Meimaridou Eirini
, Jenkinson Carl
, Rodriguez-Blanco Giovanny
, Ronchi Cristina
, Jaffri Alisha
, Metherell Louise
, Hebenstreit Daniel
, Dunn Warwick
, Arlt Wiebke
, Foster Paul
Adrenocortical Carcinoma (ACC) is an aggressive malignancy with poor response to chemotherapy. Here we evaluated a potential new treatment target for ACC, focusing on the mitochondrial NADPH generator Nicotinamide Nucleotide Transhydrogenase (NNT). NNT has a central role within mitochondrial antioxidant pathways, protecting cells from oxidative stress. Inactivating human NNT mutations result in congenital adrenal insufficiency. We hypothesized NNT silencing in ACC cells will i...